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KMID : 1044820210510060374
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Journal of Periodontal & Implant Science
2021 Volume.51 No. 6 p.374 ~ p.385
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Adjuvant therapy with 1% alendronate gel for experimental periodontitis treatment in rats
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de Campos Kajimoto Natalia
de Paiva Buischi Yvonne
Loomer Peter Michael
Bromage Timothy G.
Ervolino Edilson
Fucini Stephen Enrico
Pola Natalia Marcumini
Pirovani Beatriz Ommati
de Almeida Juliano Milanezi
Furlaneto Flavia Aparecida Chaves
Nagata Maria Jose Hitomi
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Abstract
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Purpose: The aim of this study was to evaluate the effects of locally delivered 1% alendronate (ALN) gel used as an adjunct to non-invasive periodontal therapy.
Methods: Ligature-induced periodontitis was performed in 96 rats. The ligature was tied in the cervical area of the mandibular left first molar. The animals were randomly divided into 4 groups: 1) NT, no treatment; 2) SRP, scaling and root planning; 3) SRP/PLA, SRP followed by filling the periodontal pocket with placebo gel (PLA); and 4) SRP/ALN, SRP followed by filling the periodontal pockets with 1% ALN gel. Histomorphometric (percentage of bone in the furcation region [PBF]) and immunohistochemical (receptor activator of nuclear factor-κB ligand, osteoprotegerin, and tartrate-resistant acid phosphatase) analyses were performed. Data were statistically analyzed, with the threshold of statistical significance set at P≤0.05.
Results: The SRP, SRP/PLA, and SRP/ALN groups presented a higher PBF than the NT group (P≤0.01) at 7, 15, and 30 days. The SRP/ALN group presented a higher PBF than the SRP/PLA group in all experimental periods, as well as a higher PBF than the SRP group at 15 and 30 days. No differences were observed in the immunohistochemical analyses (P>0.05 for all).
Conclusions: Locally delivered 1% ALN gel used as an adjunct to SRP enhanced bone regeneration in the furcation region in a rat model of experimental periodontitis.
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KEYWORD
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Alendronate, Dental scaling, Periodontal disease, Periodontitis, Rats
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